![]() ![]() Our results reconfirm that the guideline-recommended initial intravenous diuretic dose is feasible for AHF.ĭecongestion with intravenous (IV) diuretics is a mainstay of acute heart failure (AHF) treatment since congestion is one of the primary reasons for heart failure admission 1. Treatment with a lower than guideline-recommended intravenous diuretic dose was associated with longer HS, whereas above the guideline-recommended dose was associated with a higher 60-day mortality rate. This difference was retained after adjusting for other prognostic factors. Kaplan–Meier analysis indicated a significantly higher incidence of 60-day mortality in the Above group than the Standard group. The diuretics response and HS were significantly greater in the Below group than in the Standard group after adjusting for covariates. Of 1093 patients, 429, 558, and 106 were assigned to the Below, Standard, and Above groups, respectively. We compared the study endpoints, including 60-day mortality, diuretics response within six hours, and length of hospital stay (HS). ![]() The recommended dose was individualised based on the oral diuretic dose taken at admission. The initial intravenous diuretic dose used in each patient was categorised into below, standard, or above the recommended dose groups according to guideline-recommended initial intravenous diuretic dose. This is a post-hoc analysis of the REALITY-AHF, a prospective multicentre observational registry of AHF. Although intravenous diuretics is a cornerstone of acute heart failure treatment (AHF), its optimal initial dose is unclear. ![]()
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